Guillain-Barré Syndrome Induced by Organophosphate Poisoning: A Case Report
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Keywords
Organophosphates, Cholinesterase Inhibitors, Guillain-Barré Syndrome, Poisoning
Abstract
Introduction: Organophosphate poisoning is a common cause of intoxication in developing countries due to widespread use and poor handling practices. Objective: To report an unusual case of Guillain-Barré Syndrome (GBS) following acute organophosphate poisoning. Case presentation: A patient with acute organophosphate intoxication developed cranial nerve VI involvement, bilateral nystagmus, distal hypotonia in all four limbs, foot drop, symmetrical areflexia, and stereotyped movements. Electromyography revealed an acute sensorimotor polyradiculoneuropathy with proximal motor predominance, consistent with GBS. Conclusion: Although rare, GBS should be considered a differential diagnosis in patients presenting with progressive neuromuscular symptoms after organophosphate exposure.
References
2. Razwiedani L, Rautenbach P. Epidemiology of organophosphate poisoning in the Tshwane District of South Africa. Environ Health Insights [Internet]. 2017;11:10–3. Disponible en: http://insights.sagepub.com/epidemiology-of-organophosphate-poisoning-in-the-tshwane-district-of-s-article-a6185
3. Prüss-Ustün A, Vickers C, Haefliger P, Bertollini R. Knowns and unknowns on burden of disease due to chemicals: a systematic review. Environ Health [Internet]. 2011;10:9. Disponible en: http://ehjournal.biomedcentral.com/articles/10.1186/1476-069X-10-9
4. Thundiyil JG. Acute pesticide poisoning. Bull World Health Organ. 2008;86(3):205.
5. Lucia M, Martinez O. Protocolo de vigilancia en salud pública: intoxicaciones por sustancias químicas. Inst Nac Salud. 2013;2:1–75.
6. Domínguez Majin LJ. Caracterización epidemiológica de las intoxicaciones por plaguicidas en Colombia 2011-2012. Iqen [Internet]. 2013;18(20):222–41. Disponible en: http://www.ins.gov.co:81/iqen/IQUEN/IQEN%20vol%2018%202013%20num%2021.pdf
7. Instituto Nacional de Salud. Programa de vigilancia epidemiológica de plaguicidas organofosforados y carbamatos VEO. Informe final PICC-VEO 2015 [Internet]. 2015. Disponible en: http://www.ins.gov.co/tramites-y-servicios/programas-de-calidad/piccveo/INFORME%20FINAL%20PICC-VEO%202015.pdf
8. Instituto Nacional de Medicina Legal y Ciencias Forenses. Comportamiento del suicidio, Colombia, 2013. 2013;13:129–68.
9. London L, Bourne D, Sayed R, Eastman R. Guillain-Barré syndrome in a rural farming district in South Africa: a possible relationship to environmental organophosphate exposure. Arch Environ Health. 2004;59(11):575–80.
10. Wijdicks EFM, Klein CJ. Guillain-Barré syndrome. Mayo Clin Proc. 2017;92(3):467–79.
11. Torricelli RE. Síndrome de Guillain-Barré en pediatría. Med Buenos Aires. 2009;69(11):84.
12. Hughes RAC, Swan AV, Raphael JC, Annane D, van Koningsveld R, van Doorn PA. Immunotherapy for Guillain-Barré syndrome: a systematic review. Brain [Internet]. 2007;130(9):2245–57. Disponible en: https://academic.oup.com/brain/article-lookup/doi/10.1093/brain/awm004
13. Chio A, Cocito D, Leone M, Giordana MT, Mora G, Mutani R. Guillain-Barré syndrome: a prospective, population-based incidence and outcome survey. Neurology. 2003;60(7):1146–50.
14. Jokanović M, Kosanović M, Brkić D, Vukomanović P. Organophosphate-induced delayed polyneuropathy in man: an overview. Clin Neurol Neurosurg. 2011;113(1):7–10.
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